Humalog® (insulin lispro) injection Family of Insulins (2024)

Humalog® (insulin lispro) injection Family of Insulins (1)

Patient portrayal.

Welcome to the Humalog® Family of Insulins

Humalog mealtime insulins are used to treat people with type 1 or type 2 diabetes for the control of high blood sugar.

About Humalog

Need better control of your blood sugar? Adding Humalog to your basal insulin can help.

Humalog® (insulin lispro) injection Family of Insulins (2)

You may have been taking a long-acting insulin for a while now. So why did your doctor prescribe another insulin? Well, it's to help control the blood sugar "spikes" that happen naturally when you eat. Everyone gets them, but when you have diabetes you may need extra help controlling them. That's where Humalog comes in.

  • Humalog mealtime insulins are used to treat people with type 1 or type 2 diabetes for the control of high blood sugar.
  • Humalog is a rapid-acting insulin that starts working faster and works for a shorter period of time than regular (short-acting) insulin.
  • Taking Humalog within 15 minutes before or immediately after meals helps manage blood sugar after meals.
  • It’s important to talk to your healthcare provider about when and how often you should check your blood sugar levels.

SELECT SAFETY INFORMATION

Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro products or any of their ingredients.

Insulin Affordability

Click here for more information on Lilly’s $35/month insulin, as well as other resources that may help reduce your out-of-pocket costs for insulin therapy. Eligibility required and restrictions apply. Review full terms and conditions.

Humalog product options

Click on the brand logos below to learn more about each of the products in the Humalog Family of Insulins

Humalog® (insulin lispro) injection Family of Insulins (3)

Humalog® (insulin lispro) injection Family of Insulins (4)

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Patient portrayal.

About mealtime insulin

Mealtime insulins that contain Humalog are rapid-acting insulins that are taken right before or after meals.

Type 2 diabetes may progress over time. This does not mean that you failed. All your hard work still counts, but it means sometimes you have to change how you care for it. That's why your healthcare provider has prescribed Humalog to help lower your blood sugar.

Managing blood sugar

When using mealtime insulin like Humalog, you must test your blood sugar (glucose). For example, you may need to test before and after meals and at bedtime. Your doctor will tell you when and how often you should test.

SELECT SAFETY INFORMATION

Warnings

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3 mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Humalog® (insulin lispro) injection Family of Insulins (9)

Prescribing informationPatient InformationInstructions for Use

Humalog U-100 KwikPen® or Vial

Humalog® (insulin lispro) injection Family of Insulins (10)

Humalog U-100 KwikPen® or Vial

Learn how to use Humalog U-100 KwikPen.

Learn how to use a vial and syringe for Humalog U-100.

  • Humalog KwikPen is a small, lightweight pen that's prefilled with mealtime insulin. Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.
  • Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.
  • Humalog should be stored away from light and heat.
  • Do not use insulin if it has been frozen.
  • Opened vials should be kept at room temperature or in a refrigerator. Opened cartridges or prefilled pens should be kept at room temperature.
  • Once opened, Humalog vials, prefilled pens, and cartridges should be thrown away after 28 days even if it still contains insulin.

*Store at room temperature below 86˚F.

Learn how to use Humalog U-100 KwikPen.

Learn how to use a vial and syringe for Humalog U-100.

Use of Humalog U-100 in an insulin pump

Humalog® (insulin lispro) injection Family of Insulins (11)

Use of Humalog U-100 in an insulin pump

For some people, an insulin pump can help improve diabetes management and make it more flexible.1 A pump may be a good option if any of these apply:

  • You regularly test your blood sugar
  • You are active and have an inconsistent meal and physical activity schedule
  • You have demonstrated the ability to manage your diabetes but don't want to draw attention to it

Have your healthcare team discuss the pros and cons of external insulin pumps with you. They can help you decide whether taking Humalog with an external insulin pump is right for you.

SELECT SAFETY INFORMATION

Warnings

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Humalog® (insulin lispro) injection Family of Insulins (12)

Prescribing informationPatient InformationInstructions for Use

Humalog U-100 Junior KwikPen®

Humalog® (insulin lispro) injection Family of Insulins (13)

Humalog U-100 Junior KwikPen®

Learn how to Use Humalog U-100 Junior KwikPen.

  • Humalog Junior KwikPen is a prefilled pen with half-unit dosing capability, enabling finer dose adjustment for those who need it.
  • Humalog Junior KwikPen is a small lightweight pen that's prefilled with Humalog U-100 mealtime insulin.
  • Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.
  • *Once you start using Humalog Junior KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains Humalog.
  • The Humalog Junior KwikPen offers rapid-acting insulin, right when you need it, to help you control your diabetes.

Learn how to Use Humalog U-100 Junior KwikPen.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Humalog U-200 KwikPen

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Humalog U-200 KwikPen

Learn how to use Humalog U-200 KwikPen.

Humalog U-200 KwikPen is the same familiar design as the Humalog U-100 KwikPen. When comparing the two, you'll notice some meaningful differences and similarities:

  • Humalog U-200 KwikPen is a small, lightweight pen that’s prefilled with Humalog U-200 mealtime insulin. Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.

*Once you start using Humalog U-200 KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains insulin.

Humalog U-200 KwikPen is the same familiar design as the Humalog U-100 KwikPen. When comparing the two, you'll notice some meaningful differences and similarities:

Differences

  • Humalog U-200 KwikPen holds double the mealtime insulin* as U-100 pens.
  • With Humalog U-200 KwikPen, you'll change pens half as often.*†
  • With Humalog U-200 KwikPen, you will need fewer pens per month.*

Similarities

  • It is the same size as the Humalog U-100 KwikPen
  • No dose calculations or conversions are needed to use Humalog U-200 KwikPen.
  • Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.

*As compared with U-100 mealtime insulin pens.

Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.

Please see Instructions for Use included with your pen or click here.

Learn how to use Humalog U-200 KwikPen.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

About Humalog mixes

Humalog® (insulin lispro) injection Family of Insulins (18)

Learn how to useHumalog Mix 75/25 KwikPen andHumalog Mix 50/50 KwikPen.

Humalog Mix75/25 and Humalog Mix50/50 are combinations of rapid-acting and intermediate-acting insulin that work together to help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

Learn how to useHumalog Mix 75/25 KwikPen andHumalog Mix 50/50 KwikPen.

Other ways to take Humalog mixes

Humalog® (insulin lispro) injection Family of Insulins (19)

Learn how to use a vial and syringe forHumalog Mix 75/25 andHumalog Mix 50/50.

There are other ways to take Humalog mixes besides the KwikPen. Both premixed insulins are available in a vial. You and your doctor should discuss which option would be best for you.

Learn how to use a vial and syringe forHumalog Mix 75/25 andHumalog Mix 50/50.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Click on the brand below to learn more

Humalog® (insulin lispro) injection Family of Insulins (20)

Prescribing informationPatient InformationInstructions for Use

Humalog U-100 KwikPen® or Vial

Humalog® (insulin lispro) injection Family of Insulins (21)

Humalog U-100 KwikPen® or Vial

Learn how to use Humalog U-100 KwikPen.

Learn how to use a vial and syringe for Humalog U-100.

  • Humalog KwikPen is a small, lightweight pen that's prefilled with mealtime insulin. Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.
  • Unopened Humalog should be stored in a refrigerator and can be used until the expiration date on the carton or label.
  • Humalog should be stored away from light and heat.
  • Do not use insulin if it has been frozen.
  • Opened vials should be kept at room temperature or in a refrigerator. Opened cartridges or prefilled pens should be kept at room temperature.
  • Once opened, Humalog vials, prefilled pens, and cartridges should be thrown away after 28 days even if it still contains insulin.

*Store at room temperature below 86˚F.

Learn how to use Humalog U-100 KwikPen.

Learn how to use a vial and syringe for Humalog U-100.

Use of Humalog U-100 in an insulin pump

Humalog® (insulin lispro) injection Family of Insulins (22)

Use of Humalog U-100 in an insulin pump

For some people, an insulin pump can help improve diabetes management and make it more flexible.1 A pump may be a good option if any of these apply:

  • You regularly test your blood sugar
  • You are active and have an inconsistent meal and physical activity schedule
  • You have demonstrated the ability to manage your diabetes but don't want to draw attention to it

Have your healthcare team discuss the pros and cons of external insulin pumps with you. They can help you decide whether taking Humalog with an external insulin pump is right for you.

SELECT SAFETY INFORMATION

Warnings

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Humalog® (insulin lispro) injection Family of Insulins (23)

Prescribing informationPatient InformationInstructions for Use

Humalog U-100 Junior KwikPen®

Humalog® (insulin lispro) injection Family of Insulins (24)

Humalog U-100 Junior KwikPen®

Learn how to Use Humalog U-100 Junior KwikPen.

  • Humalog Junior KwikPen is a prefilled pen with half-unit dosing capability, enabling finer dose adjustment for those who need it.
  • Humalog Junior KwikPen is a small lightweight pen that's prefilled with Humalog U-100 mealtime insulin.
  • Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.
  • *Once you start using Humalog Junior KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains Humalog.
  • The Humalog Junior KwikPen offers rapid-acting insulin, right when you need it, to help you control your diabetes.

Learn how to Use Humalog U-100 Junior KwikPen.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Humalog® (insulin lispro) injection Family of Insulins (25)

Prescribing informationPatient InformationInstructions for Use

Humalog U-200 KwikPen

Humalog® (insulin lispro) injection Family of Insulins (26)

Humalog U-200 KwikPen

Learn how to use Humalog U-200 KwikPen.

Humalog U-200 KwikPen is the same familiar design as the Humalog U-100 KwikPen. When comparing the two, you'll notice some meaningful differences and similarities:

  • Humalog U-200 KwikPen is a small, lightweight pen that’s prefilled with Humalog U-200 mealtime insulin. Plus, since it shouldn't be refrigerated after the first use*, you can take it just about anywhere. You can carry it in your purse, backpack, or pocket because it's the size of a marker.

*Once you start using Humalog U-200 KwikPen, it should be stored at room temperature, below 86˚F (30˚C), and must be used within 28 days or be discarded, even if it still contains insulin.

Humalog U-200 KwikPen is the same familiar design as the Humalog U-100 KwikPen. When comparing the two, you'll notice some meaningful differences and similarities:

Differences

  • Humalog U-200 KwikPen holds double the mealtime insulin* as U-100 pens.
  • With Humalog U-200 KwikPen, you'll change pens half as often.*†
  • With Humalog U-200 KwikPen, you will need fewer pens per month.*

Similarities

  • It is the same size as the Humalog U-100 KwikPen
  • No dose calculations or conversions are needed to use Humalog U-200 KwikPen.
  • Once your KwikPen is opened and used for the first time, it should not be refrigerated and can be used for up to 28 days. After 28 days, the KwikPen should be discarded even if insulin remains.

*As compared with U-100 mealtime insulin pens.

Once opened, Humalog U-200 KwikPen should be thrown away after 28 days, even if insulin remains.

Please see Instructions for Use included with your pen or click here.

Learn how to use Humalog U-200 KwikPen.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

About Humalog mixes

Humalog® (insulin lispro) injection Family of Insulins (29)

Learn how to useHumalog Mix 75/25 KwikPen andHumalog Mix 50/50 KwikPen.

Humalog Mix75/25 and Humalog Mix50/50 are combinations of rapid-acting and intermediate-acting insulin that work together to help manage your blood sugar between meals and at night, as well as blood sugar "spikes" that can happen when you eat.

Learn how to useHumalog Mix 75/25 KwikPen andHumalog Mix 50/50 KwikPen.

Other ways to take Humalog mixes

Humalog® (insulin lispro) injection Family of Insulins (30)

Learn how to use a vial and syringe forHumalog Mix 75/25 andHumalog Mix 50/50.

There are other ways to take Humalog mixes besides the KwikPen. Both premixed insulins are available in a vial. You and your doctor should discuss which option would be best for you.

Learn how to use a vial and syringe forHumalog Mix 75/25 andHumalog Mix 50/50.

SELECT SAFETY INFORMATION

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Getting started on Humalog

Everyone's experience with mealtime insulin is different. For people with diabetes starting Humalog, here are some things to expect:

Humalog® (insulin lispro) injection Family of Insulins (31)

Insulin dose changes

Your Humalog dose will probably change over time. Your doctor gave you a starting dose, but most people need to increase their Humalog dose after the first day.

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Blood sugar variations

When you track your blood sugar every day, you will probably see different numbers all the time. These variations in your blood sugar from day to day are normal.

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Changes are normal

Your blood sugar varies based on stress, what you eat, other medications, exercise, and other factors. Don't beat yourself up when you see changes in your blood sugar. With your doctor's input, these variations may provide learning opportunities.

SELECT SAFETY INFORMATION

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. Do not inject your insulin into the exact same spot or where the skin has pit or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

Here are a few things to remember when you get started:

  • Humalog is a rapid-acting insulin that's taken within 15 minutes before you eat or right after eating a meal.
  • Low blood sugar is a possible serious side effect of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 that can lead to death.
  • Low blood sugar can cause dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood change, and hunger.
  • If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
  • Make sure you understand how many units of Humalog your doctor wants you to take and with what meals.

Where to inject Humalog

There are many areas on your body where you can inject your insulin. It's important to change injection sites and not overuse any site.

You can inject your dose of Humalog under the skin of your stomach area, back of upper arm, upper leg, or buttocks (see diagram). Never inject Humalog into a muscle or vein. Work with your doctor to determine what the most appropriate injection sites are for you.

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Humalog® (insulin lispro) injection Family of Insulins (35)

SELECT SAFETY INFORMATION

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Storage and disposal

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Unopened Humalog should be stored in a refrigerator at 36° to 46°F (2° to 8°C) and can be used until the expiration date on the carton or label.

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Opened prefilled pens should be kept at room temperature, below 86°F (30°C). Opened vials should be kept at room temperature or in a refrigerator.

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Do not freeze and do not use Humalog if it has been frozen.

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Humalog should be stored away from light and heat.

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Opened Humalog vials, prefilled pens, and cartridges must be thrown away 28 days after first use, even if they still contain insulin.

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Opened Humalog Mix50/50 and Humalog Mix75/25 prefilled pens must be thrown away 10 days after first use, even if they still contain insulin.

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Safely dispose of needles and pens as directed in the KwikPen Instructions for Use.

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Using Humalog with a Tempo Pen

The Tempo Pen functions in a similar way to the prefilled insulin KwikPen® and is modified to work with the Tempo Smart Button.

The Tempo Personalized Diabetes Management Platform is designed to assist you in the self-management of your diabetes. Tempo brings your information into one place, which may help you and your healthcare professional make decisions about your treatment.

Warning: The Tempo Personalized Diabetes Management Platform is intended to help support the management of your diabetes. You must continue to independently manage your glucose values and your prescribed regimen with support from your healthcare practitioner.

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The actual pen color and the physical pen many vary from the illustration based on insulin brand used. Smartphone not included with the Tempo Personalized Diabetes Management Platform.

References

  1. Grunberger G et al. Endocr Pract. 2010;16:746-762

INDICATIONS

Humalog® (HU-ma-log) and Insulin Lispro Injection are fast-acting insulins used to control high blood sugar in adults and children with diabetes.

  • Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.
  • It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Humalog® Mix50/50, Humalog®Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixed U-100 insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes.

  • It is not known if Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are safe and effective for children younger than 18 years of age. There were no studies done with these insulins in children younger than 18. If your doctor decides to give your child one of these insulins, he or she may give you special instructions.

Insulin Lispro products are Humalog. Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 contain insulin lispro protamine mixed with insulin lispro.

SAFETY SUMMARY

Warnings -

Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have:

  • symptoms of low blood sugar (hypoglycemia)
  • an allergy to insulin lispro products or any of their ingredients.

Do not reuse needles or share your insulin injection supplies with other people. This includes your:

  • prefilled pen for use by a single patient
  • cartridges
  • reusable pen that works with Lilly 3 mL cartridges
  • needles
  • syringes

You or the other person can get a serious infection. This can happen even if you change the needle.

Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.

Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.

Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death. The possible serious side effects are:

  • Low blood sugar. This can cause:
    • dizziness or light-headedness
    • headache
    • shakiness
    • irritability
    • sweating
    • blurred vision
    • fast heartbeat
    • mood change
    • confusion
    • slurred speech
    • anxiety
    • hunger

    If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon rescue medication. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.

  • Severe allergic reaction.
    Get emergency help right away if you have:
    • a rash over your whole body
    • sweating
    • extreme drowsiness
    • swelling of your face, tongue, or throat
    • trouble breathing
    • a faint feeling
    • dizziness
    • a fast heartbeat
    • shortness of breath
    • confusion
  • Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
  • Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or "TZDs," with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product.
  • High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.

Common side effects

The most common side effects of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are:

  • low blood sugar
  • reactions where you have injected insulin
  • swelling of your hands or feet
  • itching
  • allergic reactions
  • changes in fat tissue where you have injected insulin
  • weight gain
  • rash

These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:

  • about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
  • about any other prescription medicines you take, especially ones called TZDs.
  • about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
  • if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.

How to take

Read the Instructions for Use that come with your Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.

Before injecting your insulin lispro product

You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:

  • Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
  • Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
  • Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.

When you are ready to inject

  • If you are taking Humalog or Insulin Lispro Injection, inject it under your skin within 15 minutes before or right after you eat a meal.
  • If you are taking Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, inject it under your skin within 15 minutes before you eat a meal.

Staying safe while taking your insulin lispro product

To stay safe while taking your insulin, be sure to never inject Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 in your vein, muscle, or with an insulin pump. Also be sure not to:

  • mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids.
  • drive or use heavy machinery until you know how your insulin lispro product affects you.
  • drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product.

Learn more

Humalog, Humalog Mix50/50, Humalog Mix75/25, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix 75/25 are prescription medicines. For more information, call 1-800-545-5979.

This summary provides basic information about Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you.

HI BOI SP U100 75/25 CON BS 22NOV2023

Humalog®, Humalog® Mix50/50, and Humalog® Mix75/25 are trademarks and registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Humalog® (insulin lispro) injection Family of Insulins (2024)

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